Professional Replacement Cartridges for Microneedling and Nano-Infusion
Keep your Hydra Pen treatment setup ready with replacement needle cartridges designed for compatible Hydra Pen H3 and H5 microneedling devices. Available in five cartridge configurations — H12, H24, H36, Nano-HS, and Nano-HR — these replacement heads allow estheticians and skincare professionals to select the cartridge configuration according to the treatment area, application technique, and desired treatment intensity.
Each cartridge is designed as a replaceable treatment head for compatible Hydra Pen systems, helping maintain a clean and consistent workflow between treatments.
Available Options: H12 • H24 • H36 • Nano-HS • Nano-HR
Compatible Devices: Hydra Pen H3 / Hydra Pen H5
Product Type: Replacement Microneedling & Nano Cartridges
Application: Professional Aesthetic & Skincare Use


Key Features
1. Five Cartridge Options for Different Treatment Approaches
Choose from five configurations to match different treatment areas and treatment techniques:
- H12 – 12-pin configuration for more targeted treatment areas
- H24 – 24-pin configuration for balanced coverage across facial areas
- H36 – 36-pin configuration for broader treatment coverage
- Nano-HS – nano-style cartridge for superficial skincare applications
- Nano-HR – nano-style cartridge for gentle surface-level treatments and product application
The different cartridge configurations give professionals more flexibility when building a microneedling or nano-infusion treatment protocol.
2. Designed for Compatible Hydra Pen H3 & H5 Devices
These replacement cartridges are designed for use with compatible Hydra Pen H3 and Hydra Pen H5 devices.
If you are replacing used cartridges or maintaining multiple treatment setups, keeping several cartridge configurations available can make treatment preparation more efficient.
Important: Please verify your device model and cartridge connection before ordering. These cartridges are replacement accessories and are not the Hydra Pen device itself.
3. Select the Right Cartridge Configuration
Different cartridge designs can provide different levels of coverage and treatment characteristics.
| Cartridge | Configuration | General Application |
|---|---|---|
| H12 | 12 pins | Targeted facial areas and precision-oriented applications |
| H24 | 24 pins | Facial treatments requiring balanced coverage |
| H36 | 36 pins | Larger treatment areas and higher-density coverage |
| Nano-HS | Nano | Superficial skincare and nano-infusion applications |
| Nano-HR | Nano | Gentle surface-level skincare applications |
The cartridge should be selected according to the device, treatment protocol, treatment area, and professional experience.

H12, H24 & H36 Microneedling Cartridges
The H12, H24, and H36 configurations are designed around different pin counts, allowing professionals to adjust the treatment setup according to the working area and preferred coverage.
H12 – 12-Pin Cartridge
The H12 cartridge provides a lower pin-count configuration for applications where a more targeted treatment pattern is preferred.
Suitable for:
- Smaller facial areas
- Targeted skincare treatments
- Areas requiring greater maneuverability
- Professional microneedling protocols
The 12-pin format can be useful when precision and controlled coverage are more important than treating a larger area quickly.
H24 – 24-Pin Cartridge
The H24 provides a middle-density configuration designed for balanced coverage.
Suitable for:
- General facial treatments
- Cheeks
- Forehead
- Chin
- Other medium-sized treatment areas
It offers a practical option for professionals who want a versatile cartridge configuration for routine microneedling treatments.
H36 – 36-Pin Cartridge
The H36 cartridge features a higher pin count for broader treatment coverage.
Suitable for:
- Larger facial areas
- Body skincare applications where appropriate
- Treatment protocols requiring broader coverage
- Professional aesthetic treatment workflows
The higher pin count provides a denser cartridge configuration, making it useful when treating larger areas.
Nano-HS & Nano-HR Cartridges
The Nano-HS and Nano-HR options are designed for nano-style skincare applications rather than conventional deeper microneedling.
These cartridge types can be incorporated into professional skincare routines where the objective is focused on surface-level product application and cosmetic skin conditioning.
Nano-HS
Nano-HS is a nano-style cartridge option for superficial skincare applications.
It may be selected for:
- Serum application protocols
- Cosmetic skincare treatments
- Surface-level skin conditioning
- Gentle facial treatment routines
Nano-HR
Nano-HR provides another nano-style option for professionals who prefer a different cartridge configuration within their Hydra Pen H3/H5 workflow.
It can be used for:
- Superficial skincare applications
- Cosmetic serum application
- Gentle facial treatments
- Routine professional skincare protocols
Nano cartridges should not be treated as interchangeable with conventional microneedling needle cartridges. Always follow the cartridge and device manufacturer’s intended-use instructions.





Why Keep Replacement Hydra Pen Cartridges on Hand?
For professional treatment environments, replacement cartridges are an important part of maintaining an organized treatment workflow.
Having multiple cartridge configurations available allows practitioners to prepare the appropriate cartridge before each appointment rather than relying on a single cartridge type for every application.
Professional workflow benefits include:
Flexible cartridge selection
Choose H12, H24, H36, Nano-HS, or Nano-HR according to the treatment protocol.
Convenient replacement
Replace the treatment head when required instead of replacing the entire Hydra Pen device.
Treatment-area flexibility
Different pin configurations can be selected for different working areas.
Better treatment preparation
Keeping multiple cartridge types available makes it easier to prepare treatment supplies in advance.
Suitable for professional skincare environments
A practical accessory for estheticians, beauty professionals, salons, spas, and other qualified skincare practitioners using compatible equipment.
Microneedling Cartridge Compatibility
These replacement cartridges are intended for compatible:
- Hydra Pen H3
- Hydra Pen H5
- Hello Face Hydra.Pen Dr Pen
Before purchasing, compare your existing cartridge with the product images and confirm that the connection and cartridge format match your device.
Because Hydra Pen models and cartridge systems can vary, device compatibility should always be confirmed before use.
If you are unsure which cartridge you need, contact SalonMachines with a photo of your current device and cartridge.
How to Choose Between H12, H24 and H36
The easiest way to select a cartridge is to consider the treatment area and desired coverage.
Choose H12 when:
You need a lower pin-count configuration for more targeted areas or a precision-oriented treatment setup.
Choose H24 when:
You want a versatile option for routine facial applications with balanced coverage.
Choose H36 when:
You prefer a higher-density cartridge configuration for broader treatment areas.
Choose Nano-HS when:
Your protocol calls for a nano-style, superficial skincare application.
Choose Nano-HR when:
You prefer an alternative nano-style cartridge for gentle cosmetic skincare applications.
Pin count does not determine treatment depth. Treatment depth is controlled by the compatible device and its operating settings, while cartridge configuration primarily changes the needle arrangement and coverage characteristics.
Professional Treatment Applications
Compatible Hydra Pen cartridge systems may be incorporated into professional skincare protocols involving:
- Facial microneedling
- Skin texture-focused treatments
- Fine-line appearance care
- Cosmetic skin rejuvenation routines
- Acne-scar appearance care
- Serum application protocols
- Nano-infusion skincare
- Superficial cosmetic skin conditioning
- Professional facial treatment programs
Actual treatment suitability depends on the practitioner’s training, device settings, cartridge configuration, client condition, and applicable local regulations.
Replacement Cartridge Workflow
A consistent cartridge workflow helps professional practitioners organize treatment preparation.
Step 1 — Confirm Device Compatibility
Confirm that your device is a compatible Hydra Pen H3 or H5 model and that the selected cartridge matches the device.
Step 2 — Select the Cartridge
Choose H12, H24, H36, Nano-HS, or Nano-HR according to the treatment protocol.
Step 3 — Inspect the Cartridge
Before use, check the cartridge housing and needle/nano tip for visible damage, deformation, contamination, or other abnormalities.
Do not use a damaged cartridge.
Step 4 — Prepare the Treatment Area
Follow your professional hygiene and skin-preparation protocol before attaching and using the cartridge.
Step 5 — Attach the Cartridge Correctly
Install the cartridge according to the compatible Hydra Pen device instructions. Do not force the cartridge into place.
Step 6 — Perform the Treatment
Use the device only according to its operating instructions and your professional training.
Step 7 — Dispose of the Used Cartridge
Do not reuse a cartridge intended for single-use treatment. Dispose of used cartridges according to applicable local sharps or regulated-waste requirements.
Hygiene & Safety Considerations
Microneedling involves contact with the skin and, depending on the device settings and cartridge type, may involve penetration of the skin barrier. Proper hygiene and professional technique are therefore essential.
For professional use:
- Use a new cartridge when required by the treatment protocol.
- Never use a cartridge that is damaged or contaminated.
- Do not share a used cartridge between clients.
- Follow applicable infection-control procedures.
- Follow the operating instructions supplied with your Hydra Pen device.
- Use only compatible cartridges.
- Keep unused cartridges in their original packaging until needed.
- Store cartridges in a clean, dry environment.
- Dispose of used cartridges appropriately.
- Do not use microneedling cartridges on compromised or actively irritated skin unless specifically assessed and permitted under an appropriate professional protocol.
Important: These replacement cartridges are accessories for compatible aesthetic devices. They are not a medical treatment, and product results vary according to individual skin condition, treatment protocol, device settings, and practitioner technique.
H12 vs H24 vs H36 vs Nano-HS vs Nano-HR
| Feature | H12 | H24 | H36 | Nano-HS | Nano-HR |
|---|---|---|---|---|---|
| Cartridge type | Microneedling | Microneedling | Microneedling | Nano | Nano |
| Pin configuration | 12-pin | 24-pin | 36-pin | Nano | Nano |
| Coverage approach | More targeted | Balanced | Broader / denser | Superficial | Superficial |
| Typical use | Targeted areas | General facial use | Larger areas | Nano skincare | Nano skincare |
| Compatible device | H3 / H5* | H3 / H5* | H3 / H5* | H3 / H5* | H3 / H5* |
*Compatibility should be confirmed against the exact device and cartridge connection before use.
Product Specifications
| Specification | Details |
|---|---|
| Product Type | Replacement Needle / Nano Cartridges |
| Compatible Device | Hydra Pen H3 / Hydra Pen H5 |
| Available Options | H12, H24, H36, Nano-HS, Nano-HR |
| H12 | 12-pin cartridge |
| H24 | 24-pin cartridge |
| H36 | 36-pin cartridge |
| Nano-HS | Nano cartridge |
| Nano-HR | Nano cartridge |
| Application | Professional microneedling and nano-style skincare applications |
| Installation | Replacement cartridge system |
| Device Included | No |
| Pen Included | No |
Who Is This Product For?
These replacement cartridges are designed for qualified professionals and trained users working with compatible Hydra Pen systems, including:
- Estheticians
- Beauty professionals
- Salon owners
- Spa professionals
- Skincare practitioners
- Aesthetic treatment providers
- Professional skincare clinics
For professional environments with multiple treatment protocols, keeping several cartridge configurations in stock can simplify treatment preparation and cartridge selection.
Frequently Asked Questions
1. Are these cartridges compatible with Hydra Pen H3?
These cartridges are designed for compatible Hydra Pen H3 systems. Always confirm the cartridge connection and your exact device model before ordering.
2. Are these cartridges compatible with Hydra Pen H5?
Yes, the product is designed for compatible Hydra Pen H5 systems. Check your existing cartridge and device connection before use.
3. What cartridge options are available?
There are five options:
H12, H24, H36, Nano-HS, and Nano-HR.
4. What is the difference between H12, H24 and H36?
The primary difference is the pin configuration. H12 has 12 pins, H24 has 24 pins, and H36 has 36 pins. Different configurations provide different coverage characteristics and can be selected according to the treatment area and professional protocol.
5. What is the difference between microneedling and Nano cartridges?
H12, H24, and H36 are conventional needle cartridge configurations. Nano-HS and Nano-HR are designed for nano-style, superficial skincare applications. They should not be considered interchangeable treatment approaches.
6. Does a higher pin count mean deeper microneedling?
No. Pin count and needle depth are different variables. The cartridge determines the needle arrangement and coverage characteristics, while treatment depth is controlled by the compatible device and its settings.
7. Can I reuse the cartridge?
Do not reuse a cartridge intended for single-use treatment. Replace the cartridge according to the applicable hygiene protocol and dispose of used cartridges appropriately.
8. Does the product include the Hydra Pen?
No. This listing is for replacement cartridges only. The Hydra Pen H3/H5 device is not included.









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